ANALYSIS OF HAND ECZEMA DEVELOPMENT DEPENDING ON GLUCOCORTICOID RECEPTOR GENE BclI POLYMORPHISM
نویسندگان
چکیده
منابع مشابه
Analysis of BCLI, N363S and ER22/23EK Polymorphisms of the Glucocorticoid Receptor Gene in Adrenal Incidentalomas
CONTEXT Patients with adrenal incidentalomas (AI) may experience detrimental consequences due to a minimal cortisol excess sustained by adrenal adenoma. SNPs of the glucocorticoid receptor gene (NR3C1) modulate individual sensitivity to glucocorticoids and may interfere with the clinical presentation. OBJECTIVE To compare the frequency of N363S, ER22/23EK and BclI SNPs in patients with AI wit...
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CONTEXT Patients with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) are at a high risk of adrenal crisis (AC). Glucocorticoid sensitivity is at least partially genetically determined by polymorphisms of the glucocorticoid receptor (GR). OBJECTIVES To determine if a number of intercurrent illnesses and AC are associated with the GR gene polymorphism BclI in patien...
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Glucocorticoids seem to mediate the effect of stimulant drugs such as nicotine. Several studies have pointed to an association between the BclI polymorphism in the glucocorticoid receptor gene and increased glucocorticoid effects. We analysed the association of smoking behaviour and the BclI polymorphism using a case-control design within the framework of a larger pharmacogenetic study. A total...
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BACKGROUND The glucocorticoid receptor gene (NR3C1) has been suggested as a candidate gene affecting juvenile idiopathic arthritis (JIA) course and prognosis. The purpose of this study is to investigate the glucocorticoid receptor gene BclI polymorphism (rs41423247) in JIA patients, the gene's role in susceptibility to juvenile idiopathic arthritis, and its associations with JIA activity, cours...
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ژورنال
عنوان ژورنال: Bulletin of Problems Biology and Medicine
سال: 2020
ISSN: 2077-4214,2523-4110
DOI: 10.29254/2077-4214-2020-3-157-174-177